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Missing Links in Antibody Assembly Control
Joint Authors
van Anken, Eelco
Anelli, Tiziana
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Fidelity of the humoral immune response requires that quiescent B lymphocytes display membrane bound immunoglobulin M (IgM) on B lymphocytes surface as part of the B cell receptor, whose function is to recognize an antigen.
At the same time B lymphocytes should not secrete IgM until recognition of the antigen has occurred.
The heavy chains of the secretory IgM have a C-terminal tail with a cysteine instead of a membrane anchor, which serves to covalently link the IgM subunits by disulfide bonds to form “pentamers” or “hexamers.” By virtue of the same cysteine, unassembled secretory IgM subunits are recognized and retained (via mixed disulfide bonds) by members of the protein disulfide isomerase family, in particular ERp44.
This so-called “thiol-mediated retention” bars assembly intermediates from prematurely leaving the cell and thereby exerts quality control on the humoral immune response.
In this essay we discuss recent findings on how ERp44 governs such assembly control in a pH-dependent manner, shuttling between the cisGolgi and endoplasmic reticulum, and finally on how pERp1/MZB1, possibly as a co-chaperone of GRP94, may help to overrule the thiol-mediated retention in the activated B cell to give way to antibody secretion.
American Psychological Association (APA)
Anelli, Tiziana& van Anken, Eelco. 2013. Missing Links in Antibody Assembly Control. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-484578
Modern Language Association (MLA)
Anelli, Tiziana& van Anken, Eelco. Missing Links in Antibody Assembly Control. International Journal of Cell Biology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-484578
American Medical Association (AMA)
Anelli, Tiziana& van Anken, Eelco. Missing Links in Antibody Assembly Control. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-484578
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484578