Intraperitoneal OxygenOzone Treatment Decreases the Formation of Experimental Postsurgical Peritoneal Adhesions and the LevelsActivity of the Local Ubiquitin-Proteasome System

Joint Authors

Capuano, Annalisa
Di Filippo, Clara
Rinaldi, Barbara
Lettieri, Biagio
Luongo, Margherita
D'Amico, Michele
Rossi, Francesco

Source

Mediators of Inflammation

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-09-29

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Diseases

Abstract EN

We have investigated whether an oxygen/ozone (95%O2/5%O3) mixture would have potential against the formation of experimental postsurgical peritoneal adhesions.

In two groups of rats, one control intraperitoneally injected with 3 mL/rat of O2 and one intraperitoneally injected with oxygen/ozone mixture (3 mL/rat equivalent to 300 μg/kg ozone), we induced a midline laparotomy and an enterotomy at the level of the ileum to encourage the formation of peritoneal adhesions.

Samples were taken from the parietal peritoneal tissue to assess the formation of adhesions 0 and 10 days after the surgical procedure and to assess the levels of ubiquitin and 20S proteasome.

We found decreased formation of postsurgical peritoneal adhesions after treatment of the rats with 300 μg/kg ozone associated with a decreased levels of ubiquitin and 20S proteasome subunit within the adhered tissue.

Oxygen/ozone mixture is potentially useful for approaching the post-surgical peritoneal adhesions, and the UPS system is involved in this.

American Psychological Association (APA)

Di Filippo, Clara& Capuano, Annalisa& Rinaldi, Barbara& Luongo, Margherita& Lettieri, Biagio& Rossi, Francesco…[et al.]. 2011. Intraperitoneal OxygenOzone Treatment Decreases the Formation of Experimental Postsurgical Peritoneal Adhesions and the LevelsActivity of the Local Ubiquitin-Proteasome System. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-484581

Modern Language Association (MLA)

Di Filippo, Clara…[et al.]. Intraperitoneal OxygenOzone Treatment Decreases the Formation of Experimental Postsurgical Peritoneal Adhesions and the LevelsActivity of the Local Ubiquitin-Proteasome System. Mediators of Inflammation No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-484581

American Medical Association (AMA)

Di Filippo, Clara& Capuano, Annalisa& Rinaldi, Barbara& Luongo, Margherita& Lettieri, Biagio& Rossi, Francesco…[et al.]. Intraperitoneal OxygenOzone Treatment Decreases the Formation of Experimental Postsurgical Peritoneal Adhesions and the LevelsActivity of the Local Ubiquitin-Proteasome System. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-484581

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-484581