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Antinociceptive and Toxicological Effects of Dioclea grandiflora Seed Pod in Mice
Joint Authors
Nóbrega, Franklin Ferreira de Farias
Bhattacharyya, Jnanabrata
Oliveira, Leandra Eugênia Gomes de
Almeida, Reinaldo Nóbrega de
Sá, Rita de Cássia da Silveira e
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The acute treatment of mice with an ethanolic extract from the seed pod of Dioclea grandiflora (EDgP) at doses of 75, 150 and 300 mg/kg by intraperitoneal administration produced a significant antinociceptive effect as displayed by the acetic acid-induced writhing test and the formalin test.
The antinociception was observed through the first (neurogenic pain) and second (inflammatory pain) phases in the formalin test.
The hot plate test did not show an increase in the antinociceptive latency whereas the motor performance was affected by the administration at 300 mg/kg at the beginning (30 minutes) of the observation period but not at later periods (60 and 120 minutes).
These results suggest that EDgP has a central antinociceptive action and a possible anti-inflammatory activity in mice.
American Psychological Association (APA)
Sá, Rita de Cássia da Silveira e& Oliveira, Leandra Eugênia Gomes de& Nóbrega, Franklin Ferreira de Farias& Bhattacharyya, Jnanabrata& Almeida, Reinaldo Nóbrega de. 2010. Antinociceptive and Toxicological Effects of Dioclea grandiflora Seed Pod in Mice. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-484583
Modern Language Association (MLA)
Sá, Rita de Cássia da Silveira e…[et al.]. Antinociceptive and Toxicological Effects of Dioclea grandiflora Seed Pod in Mice. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-484583
American Medical Association (AMA)
Sá, Rita de Cássia da Silveira e& Oliveira, Leandra Eugênia Gomes de& Nóbrega, Franklin Ferreira de Farias& Bhattacharyya, Jnanabrata& Almeida, Reinaldo Nóbrega de. Antinociceptive and Toxicological Effects of Dioclea grandiflora Seed Pod in Mice. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-484583
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484583