CSF Biomarkers for Alzheimer's Disease Diagnosis
Joint Authors
Jacob, Reeba S.
Singh, Pradeep K.
Anoop, A.
Maji, Samir K.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Alzheimer's disease (AD) is the most common form of dementia that affects several million people worldwide.
The major neuropathological hallmarks of AD are the presence of extracellular amyloid plaques that are composed of Aβ40 and Aβ42 and intracellular neurofibrillary tangles (NFT), which is composed of hyperphosphorylated protein Tau.
While the amyloid plaques and NFT could define the disease progression involving neuronal loss and dysfunction, significant cognitive decline occurs before their appearance.
Although significant advances in neuroimaging techniques provide the structure and physiology of brain of AD cases, the biomarker studies based on cerebrospinal fluid (CSF) and plasma represent the most direct and convenient means to study the disease progression.
Biomarkers are useful in detecting the preclinical as well as symptomatic stages of AD.
In this paper, we discuss the recent advancements of various biomarkers with particular emphasis on CSF biomarkers for monitoring the early development of AD before significant cognitive dysfunction.
American Psychological Association (APA)
Anoop, A.& Singh, Pradeep K.& Jacob, Reeba S.& Maji, Samir K.. 2010. CSF Biomarkers for Alzheimer's Disease Diagnosis. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-484590
Modern Language Association (MLA)
Anoop, A.…[et al.]. CSF Biomarkers for Alzheimer's Disease Diagnosis. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-484590
American Medical Association (AMA)
Anoop, A.& Singh, Pradeep K.& Jacob, Reeba S.& Maji, Samir K.. CSF Biomarkers for Alzheimer's Disease Diagnosis. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-484590
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484590