Iron and Neurodegeneration in Multiple Sclerosis
Joint Authors
Teunissen, Charlotte E.
Langkammer, Christian
Khalil, Michael
Source
Multiple Sclerosis International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Increased iron deposition might be implicated in multiple sclerosis (MS).
Recent development of MRI enabled to determine brain iron levels in a quantitative manner, which has put more interest on studying the role of iron in MS.
Evidence for abnormal iron homeostasis in MS comes also from analyses of iron and iron-related proteins in CSF and blood and postmortem MS brain sections.
However, it is not yet clear if iron accumulation is implicated in MS pathology or merely reflects an epiphenomenon.
Further interest has been generated by the idea of chronic cerebrospinal venous insufficiency that might be associated with brain iron accumulation due to a reduction in venous outflow, but its existence and etiologic role in MS are currently controversially debated.
In future studies, combined approaches applying quantitative MRI together with CSF and serum analyses of iron and iron-related proteins in a clinical followup setting might help to elucidate the implication of iron accumulation in MS.
American Psychological Association (APA)
Khalil, Michael& Teunissen, Charlotte E.& Langkammer, Christian. 2011. Iron and Neurodegeneration in Multiple Sclerosis. Multiple Sclerosis International،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-484591
Modern Language Association (MLA)
Khalil, Michael…[et al.]. Iron and Neurodegeneration in Multiple Sclerosis. Multiple Sclerosis International No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-484591
American Medical Association (AMA)
Khalil, Michael& Teunissen, Charlotte E.& Langkammer, Christian. Iron and Neurodegeneration in Multiple Sclerosis. Multiple Sclerosis International. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-484591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484591