A Gastrointestinal Stromal Tumor of the Stomach Demonstrating a Stepwise Progression from Low- to High-Grade Malignancy
Joint Authors
Ushijima, Tomonori
Tsuneyama, Koichi
Kihara, Atsushi
Fukushima, Junichi
Nakajima, Takahiko
Sugiyama, Toshiro
Murata, Kenichiro
Murakami, Jun
Horiuchi, Hajime
Source
Case Reports in Gastrointestinal Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-26
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
We report a case of a gastrointestinal stromal tumor (GIST) of the stomach that demonstrated a stepwise progression from low- to high-grade malignancy.
The patient had been followed for a small gastric submucosal tumor that had turned malignant after 8 years of indolence, manifested by tarry stools.
The tumor was enucleated, and gastric GIST was diagnosed.
The most significant histological finding was that the tumor comprised two clearly demarcated areas, one with less aggressive characteristics and the other with highly aggressive characteristics.
The patient exhibited multiple liver metastases 24 months after surgery.
Imatinib mesylate was not administered throughout the clinical course because it was not available for clinical use at that time.
The patient followed an unfavorable clinical course and died of liver dysfunction 55 months after surgery.
Autopsy was performed.
By comparing the immunohistochemical profiles of primary and metastatic tumors, it was established that only the tumor cells with highly aggressive characteristics had metastasized.
American Psychological Association (APA)
Nakajima, Takahiko& Ushijima, Tomonori& Kihara, Atsushi& Murata, Kenichiro& Sugiyama, Toshiro& Tsuneyama, Koichi…[et al.]. 2012. A Gastrointestinal Stromal Tumor of the Stomach Demonstrating a Stepwise Progression from Low- to High-Grade Malignancy. Case Reports in Gastrointestinal Medicine،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-484593
Modern Language Association (MLA)
Nakajima, Takahiko…[et al.]. A Gastrointestinal Stromal Tumor of the Stomach Demonstrating a Stepwise Progression from Low- to High-Grade Malignancy. Case Reports in Gastrointestinal Medicine No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-484593
American Medical Association (AMA)
Nakajima, Takahiko& Ushijima, Tomonori& Kihara, Atsushi& Murata, Kenichiro& Sugiyama, Toshiro& Tsuneyama, Koichi…[et al.]. A Gastrointestinal Stromal Tumor of the Stomach Demonstrating a Stepwise Progression from Low- to High-Grade Malignancy. Case Reports in Gastrointestinal Medicine. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-484593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484593