CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation
Joint Authors
Schonland, Stefan O.
Gürel, Selma
Perz, Jolanta B.
Dreger, Peter
Ho, Anthony D.
Hegenbart, Ute
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Background.
The therapeutic efficacy of allogeneic hemopoietic stem cell transplantation (HSCT) largely relies on the graft-versus-leukemia (GVL) effect.
Uncontrolled graft-versus-host disease (GVHD) is a feared complication of HSCT.
Regulatory T cells (Treg) are a subset of CD4+ T-helper cells believed to maintain tolerance after HSCT.
It remains unclear whether low peripheral blood Treg have an impact on the risk for acute (aGVHD) and chronic GVHD (cGVHD).
Methods.
In this paper we enumerated the CD4+CD25highCD127low Treg in the peripheral blood of 84 patients after at least 150 days from HSCT and in 20 healthy age-matched controls.
Results.
Although similar mean lymphocyte counts were found in patients and controls, CD3+CD4+ T-cell counts were significantly lower in patients.
Patients also had significantly lower Treg percentages among lymphocytes as compared to controls.
Patients with cGVHD had even higher percentages of Treg if compared to patients without cGVHD.
In multivariate analysis, Treg percentages were not an independent factor for cGVHD.
Conclusions.
This paper did not show a relation between deficient peripheral blood Treg and cGVHD, therefore cGVHD does not seem to occur as a result of peripheral Treg paucity.
American Psychological Association (APA)
Perz, Jolanta B.& Gürel, Selma& Schonland, Stefan O.& Hegenbart, Ute& Ho, Anthony D.& Dreger, Peter. 2012. CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-484594
Modern Language Association (MLA)
Perz, Jolanta B.…[et al.]. CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation. The Scientific World Journal No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-484594
American Medical Association (AMA)
Perz, Jolanta B.& Gürel, Selma& Schonland, Stefan O.& Hegenbart, Ute& Ho, Anthony D.& Dreger, Peter. CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-484594
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484594