Accelerated Atherosclerosis in Systemic Lupus Erythematosus : Role of Proinflammatory Cytokines and Therapeutic Approaches
Joint Authors
Aguirre, Maria Ángeles
Barbarroja, Nuria
López-Pedrera, Chary
Cuadrado, Maria José
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE), a chronic multisystem autoimmune disease with a broad range of clinical manifestations, is associated with accelerated atherosclerosis (AT) and increased risk of cardiovascular complications.
Relevant factors directly influencing the development of AT comprise immune complex generation, complement activation, and changes in the production and activity of a complex network of cytokines, including type I and II interferons, B lymphocyte stimulator (BLyS), TNFα, IL-6, IL-17 and migration macrophage inhibitor (MIF).
Autoantibodies, also responsible for cytokine expression and activation, play a supplementary key role in the development of AT.
Genomic and proteomic studies have contributed to the discovery of genes and proteins involved in AT, including some that may be suitable to be used as biomarkers.
All that data has allowed the development of new drugs, most of them evaluated in clinical trials: inhibitors of IFN and TNFα, B cell directed therapies, synthetic oligodeoxynucleotides, intravenous immunoglobulin, or statins.
The focus of the present paper is to summarize recent evidence showing the role of cytokines in the development of AT in SLE and the rationale, and safety concerns, in the use of combined therapy to prevent AT and cardiovascular disease.
American Psychological Association (APA)
López-Pedrera, Chary& Aguirre, Maria Ángeles& Barbarroja, Nuria& Cuadrado, Maria José. 2010. Accelerated Atherosclerosis in Systemic Lupus Erythematosus : Role of Proinflammatory Cytokines and Therapeutic Approaches. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-484616
Modern Language Association (MLA)
López-Pedrera, Chary…[et al.]. Accelerated Atherosclerosis in Systemic Lupus Erythematosus : Role of Proinflammatory Cytokines and Therapeutic Approaches. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-484616
American Medical Association (AMA)
López-Pedrera, Chary& Aguirre, Maria Ángeles& Barbarroja, Nuria& Cuadrado, Maria José. Accelerated Atherosclerosis in Systemic Lupus Erythematosus : Role of Proinflammatory Cytokines and Therapeutic Approaches. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-484616
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484616