Transient Monoclonal Gammopathy Induced by Disseminated Staphylococcus aureus Infection

Abstract EN

Monoclonal gammopathy reflects a serological disorder suggesting a plasma cell dyscrasia or a B-cell abnormality.

However, it may occasionally be encountered as a transient manifestation in the course of several diseases including infections.

This is the first reported case of a transient monoclonal gammopathy IgG lambda light chain associated with a Staphylococcus aureus infection that was complicated with renal abscess and vertebral spondylodiscitis in a previously healthy 68-year-old male.

We observed a complete resolution of the gammopathy within three months of medical treatment before the entire restoration of all clinical and laboratory findings.

Many invasive and cost-intensive diagnostic procedures had preceded the exclusion of a malignancy.

The clinical significance and the exact pathogenesis of transient monoclonality are poorly understood and remain a matter of speculation.