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Neurotoxic Effects of trans-Glutaconic Acid in Rats
Joint Authors
Ferreira, Gustavo Costa
Tonin, Anelise M.
Busanello, Estela N. B.
Schuck, Patrícia Fernanda
Viegas, Carolina M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
trans-Glutaconic acid (tGA) is an unsaturated C5-dicarboxylic acid which may be found accumulated in glutaric aciduria type I, whose pathophysiology is still uncertain.
In the present work it was investigated the in vitro effect of increasing tGA concentrations on neurochemical and oxidative stress parameters in rat cerebral cortex.
We observed that Na+, K+-ATPase activity was reduced by tGA, but not creatine kinase, respiratory chain complex IV, and ATP synthase activities.
On the other hand, tGA significantly increased lipid peroxidation (thiobarbituric acid-reactive species levels and spontaneous chemiluminescence), as well as protein oxidative damage (oxidation of sulfhydryl groups).
tGA also significantly decreased nonenzymatic antioxidant defenses (TRAP and reduced glutathione levels).
Our data suggest that tGA may be neurotoxic in rat brain.
American Psychological Association (APA)
Schuck, Patrícia Fernanda& Busanello, Estela N. B.& Tonin, Anelise M.& Viegas, Carolina M.& Ferreira, Gustavo Costa. 2013. Neurotoxic Effects of trans-Glutaconic Acid in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-484670
Modern Language Association (MLA)
Schuck, Patrícia Fernanda…[et al.]. Neurotoxic Effects of trans-Glutaconic Acid in Rats. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-484670
American Medical Association (AMA)
Schuck, Patrícia Fernanda& Busanello, Estela N. B.& Tonin, Anelise M.& Viegas, Carolina M.& Ferreira, Gustavo Costa. Neurotoxic Effects of trans-Glutaconic Acid in Rats. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-484670
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484670