Mitochondrial Stress Signalling : HTRA2 and Parkinson's Disease
Joint Authors
Martins, L. Miguel
Desideri, Enrico
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Mitochondria are cellular energy generators whose activity requires a continuous supply of oxygen.
Recent genetic analysis has suggested that defects in mitochondrial quality control may be key factors in the development of Parkinson’s disease (PD).
Mitochondria have a crucial role in supplying energy to the brain, and their deterioration can affect the function and viability of neurons, contributing to neurodegeneration.
These organelles can sow the seeds of their own demise because they generate damaging oxygen-free radicals as a byproduct of their intrinsic physiological functions.
Mitochondria have therefore evolved specific molecular quality control mechanisms to compensate for the action of damaging agents such as oxygen-free radicals.
PTEN-induced putative kinase 1 (PINK1) and high-temperature-regulated A2 (HTRA2), a mitochondrial protease, have recently been proposed to be key modulators of mitochondrial molecular quality control.
Here, we review some of the most recent advances in our understanding of mitochondria stress-control pathways, focusing on how signalling by the p38 stress kinase pathway may regulate mitochondrial stress by modulating the activity of HTRA2 via PINK1 and cyclin-dependent kinase 5 (CDK5).
We also propose how defects in this pathway may contribute to PD.
American Psychological Association (APA)
Desideri, Enrico& Martins, L. Miguel. 2012. Mitochondrial Stress Signalling : HTRA2 and Parkinson's Disease. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-484693
Modern Language Association (MLA)
Desideri, Enrico& Martins, L. Miguel. Mitochondrial Stress Signalling : HTRA2 and Parkinson's Disease. International Journal of Cell Biology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-484693
American Medical Association (AMA)
Desideri, Enrico& Martins, L. Miguel. Mitochondrial Stress Signalling : HTRA2 and Parkinson's Disease. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-484693
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484693