A Pilot Study Evaluating the Contribution of SLC19A1 (RFC-1) 80G>A Polymorphism to Alzheimer’s Disease in Italian Caucasians
Joint Authors
Migliore, Lucia
Tognoni, Gloria
Tannorella, Pierpaola
Sorbi, Sandro
Siciliano, Gabriele
Nacmias, Benedetta
Bongioanni, Paolo
Bagnoli, Silvia
Bonuccelli, Ubaldo
Coppedè, Fabio
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is the most common neurodegenerative disorder and the primary form of dementia in the elderly.
Polymorphisms of genes involved in folate metabolism have been frequently suggested as risk factors for sporadic AD.
A common c.80G>A polymorphism (rs1051266) in the gene coding for the reduced folate carrier (SLC19A1 gene, commonly known as RFC-1 gene) was investigated as AD risk factor in Asian populations, yielding conflicting results.
We screened a Caucasian population of Italian origin composed of 192 sporadic AD patients and 186 healthy matched controls, for the presence of the RFC-1 c.80G>A polymorphism, and searched for correlation with circulating levels of folate, homocysteine, and vitamin B12.
No difference in the distribution of allele and genotype frequencies was observed between AD patients and controls.
No correlation was observed among the genotypes generated by the RFC-1 c.80G>A polymorphism and circulating levels of folate, homocysteine, and vitamin B12 either in the whole cohort of subjects or after stratification into clinical subtypes.
Present results do not support a role for the RFC-1 c.80G>A polymorphism as independent risk factor for sporadic AD in Italian Caucasians.
American Psychological Association (APA)
Coppedè, Fabio& Tannorella, Pierpaola& Tognoni, Gloria& Bagnoli, Silvia& Bongioanni, Paolo& Nacmias, Benedetta…[et al.]. 2014. A Pilot Study Evaluating the Contribution of SLC19A1 (RFC-1) 80G>A Polymorphism to Alzheimer’s Disease in Italian Caucasians. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-484711
Modern Language Association (MLA)
Coppedè, Fabio…[et al.]. A Pilot Study Evaluating the Contribution of SLC19A1 (RFC-1) 80G>A Polymorphism to Alzheimer’s Disease in Italian Caucasians. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-484711
American Medical Association (AMA)
Coppedè, Fabio& Tannorella, Pierpaola& Tognoni, Gloria& Bagnoli, Silvia& Bongioanni, Paolo& Nacmias, Benedetta…[et al.]. A Pilot Study Evaluating the Contribution of SLC19A1 (RFC-1) 80G>A Polymorphism to Alzheimer’s Disease in Italian Caucasians. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-484711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484711