The Role of IL-33 in Gut Mucosal Inflammation
Joint Authors
Pizarro, Theresa T.
Pastorelli, Luca
Vecchi, Maurizio
De Salvo, Carlo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Interleukin (IL)-33 is a recently identified cytokine belonging to the IL-1 family that is widely expressed throughout the body and has the ability to induce Th2 immune responses.
In addition, IL-33 plays a key role in promoting host defenses against parasites through the expansion of a novel population of innate lymphoid cells.
In recent years, a growing body of evidence has shown that the proinflammatory properties displayed by IL-33 are detrimental in several experimental models of inflammation; in others, however, IL-33 appears to have protective functions.
In 2010, four different research groups consistently described the upregulation of IL-33 in patients with inflammatory bowel disease (IBD).
Animal models of IBD were subsequently utilized in order to mechanistically determine the precise role of IL-33 in chronic intestinal inflammation, without, however, reaching conclusive evidence demonstrating whether IL-33 is pathogenic or protective.
Indeed, data generated from these studies suggest that IL-33 may possess dichotomous functions, enhancing inflammatory responses on one hand and promoting epithelial integrity on the other.
This review focuses on the available data regarding IL-33/ST2 in the physiological and inflammatory states of the gut in order to speculate on the possible roles of this novel IL-1 family member in intestinal inflammation.
American Psychological Association (APA)
Pastorelli, Luca& De Salvo, Carlo& Vecchi, Maurizio& Pizarro, Theresa T.. 2013. The Role of IL-33 in Gut Mucosal Inflammation. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-484718
Modern Language Association (MLA)
Pastorelli, Luca…[et al.]. The Role of IL-33 in Gut Mucosal Inflammation. Mediators of Inflammation No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-484718
American Medical Association (AMA)
Pastorelli, Luca& De Salvo, Carlo& Vecchi, Maurizio& Pizarro, Theresa T.. The Role of IL-33 in Gut Mucosal Inflammation. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-484718
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484718