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ROS in Aging Caenorhabditis elegans : Damage or Signaling?
Joint Authors
Braeckman, Bart P.
Back, Patricia
Matthijssens, Filip
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-15
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Many insights into the mechanisms and signaling pathways underlying aging have resulted from research on the nematode Caenorhabditis elegans.
In this paper, we discuss the recent findings that emerged using this model organism concerning the role of reactive oxygen species (ROS) in the aging process.
The accrual of oxidative stress and damage has been the predominant mechanistic explanation for the process of aging for many years, but reviewing the recent studies in C.
elegans calls this theory into question.
Thus, it becomes more and more evident that ROS are not merely toxic byproducts of the oxidative metabolism.
Rather it seems more likely that tightly controlled concentrations of ROS and fluctuations in redox potential are important mediators of signaling processes.
We therefore discuss some theories that explain how redox signaling may be involved in aging and provide some examples of ROS functions and signaling in C.
elegans metabolism.
To understand the role of ROS and the redox status in physiology, stress response, development, and aging, there is a rising need for accurate and reversible in vivo detection.
Therefore, we comment on some methods of ROS and redox detection with emphasis on the implementation of genetically encoded biosensors in C.
elegans.
American Psychological Association (APA)
Back, Patricia& Braeckman, Bart P.& Matthijssens, Filip. 2012. ROS in Aging Caenorhabditis elegans : Damage or Signaling?. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-484749
Modern Language Association (MLA)
Back, Patricia…[et al.]. ROS in Aging Caenorhabditis elegans : Damage or Signaling?. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-484749
American Medical Association (AMA)
Back, Patricia& Braeckman, Bart P.& Matthijssens, Filip. ROS in Aging Caenorhabditis elegans : Damage or Signaling?. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-484749
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484749