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Fast Parameters Estimation in Medication Efficacy Assessment Model for Heart Failure Treatment
Joint Authors
Yang, Guiqiu
Gong, Shijin
Cai, Guolong
Fu, Xiao
Yan, Jing
Li, Li
Lin, Chengyu
Ning, Gangmin
Pan, Qing
Ren, Yinzi
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
Heart failure (HF) is a common and potentially fatal condition.
Cardiovascular research has focused on medical therapy for HF.
Theoretical modelling could enable simulation and evaluation of the effectiveness of medications.
Furthermore, the models could also help predict patients’ cardiac response to the treatment which will be valuable for clinical decision-making.
Methods.
This study presents a fast parameters estimation algorithm for constructing a cardiovascular model for medicine evaluation.
The outcome of HF treatment is assessed by hemodynamic parameters and a comprehensive index furnished by the model.
Angiotensin-converting enzyme inhibitors (ACEIs) were used as a model drug in this study.
Results.
Our simulation results showed different treatment responses to enalapril and lisinopril, which are both ACEI drugs.
A dose-effect was also observed in the model simulation.
Conclusions.
Our results agreed well with the findings from clinical trials and previous literature, suggesting the validity of the model.
American Psychological Association (APA)
Ren, Yinzi& Fu, Xiao& Pan, Qing& Lin, Chengyu& Yang, Guiqiu& Li, Li…[et al.]. 2012. Fast Parameters Estimation in Medication Efficacy Assessment Model for Heart Failure Treatment. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-484769
Modern Language Association (MLA)
Ren, Yinzi…[et al.]. Fast Parameters Estimation in Medication Efficacy Assessment Model for Heart Failure Treatment. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-484769
American Medical Association (AMA)
Ren, Yinzi& Fu, Xiao& Pan, Qing& Lin, Chengyu& Yang, Guiqiu& Li, Li…[et al.]. Fast Parameters Estimation in Medication Efficacy Assessment Model for Heart Failure Treatment. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-484769
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484769