![](/images/graphics-bg.png)
Paraneoplastic Limbic Encephalitis Resembling Acute Herpetic Encephalitis
Joint Authors
Gkekas, Georgios
Papathanasiou, Athanasios
Markakis, Ioannis
Siarkos, Kostantinos
Papageorgiou, Ermioni
Source
Case Reports in Neurological Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-27
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Introduction.
Paraneoplastic limbic encephalitis (PLE) is a rare disorder that typically follows a chronic or subacute course of personality changes, memory loss, seizures, and hallucinations.
Early diagnosis is difficult and characteristic symptoms can be mimicked by a variety of conditions.
We present a case of PLE, initially presenting as acute herpetic encephalitis.
Case Presentation.
A 56-year-old male was admitted for evaluation of acute onset headache, fever, and confusion.
On neurological examination he was confused with MMSE score of 15/30.
CSF analysis revealed marked lymphocytic pleocytosis.
A possible diagnosis of acute herpetic encephalitis was rendered and patient was treated with acyclovir.
CSF PCR was negative.
Cranial MRI revealed bilateral hyperintense lesions in medial temporal lobes with contrast enhancement.
Despite treatment with acyclovir patient was deteriorated; thus, a paraneoplastic syndrome was suspected.
Chest CT showed a right paratracheal lymph node mass, while a biopsy revealed neuroendocrine lung cancer.
Auto antibodies to Hu were also detected.
The patient was treated with steroids and chemotherapy.
Six months later, he had complete tumour remission and marked neurological improvement.
Discussion.
PLE can rarely invade acutely, being indistinguishable from herpetic encephalitis.
Inclusion of PLE in the differential diagnosis of acute encephalitis is of great clinical significance.
American Psychological Association (APA)
Markakis, Ioannis& Papathanasiou, Athanasios& Papageorgiou, Ermioni& Siarkos, Kostantinos& Gkekas, Georgios. 2013. Paraneoplastic Limbic Encephalitis Resembling Acute Herpetic Encephalitis. Case Reports in Neurological Medicine،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-484771
Modern Language Association (MLA)
Markakis, Ioannis…[et al.]. Paraneoplastic Limbic Encephalitis Resembling Acute Herpetic Encephalitis. Case Reports in Neurological Medicine No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-484771
American Medical Association (AMA)
Markakis, Ioannis& Papathanasiou, Athanasios& Papageorgiou, Ermioni& Siarkos, Kostantinos& Gkekas, Georgios. Paraneoplastic Limbic Encephalitis Resembling Acute Herpetic Encephalitis. Case Reports in Neurological Medicine. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-484771
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484771