The Global Transcriptional Response of Isolated Human Islets of Langerhans to Glucagon-Like Peptide-1 Receptor Agonist Liraglutide
Joint Authors
Tang, Yongming G.
Su, Xiaogang
Hui, Hongxiang
Go, Vay Liang W.
Cai, Dehong
Khoury, Nasif
Wang, Charles
Wu, S. Vincent
He, Fang
Zhao, Xiaoning
Perfetti, Ricardo
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
GLP-1 and its analog have been used in diabetes treatment; however, the direct alteration of gene expression profile in human islets induced by GLP-1 has not been reported.
In present study, transcriptional gene expression in the liraglutide-treated human islets was analyzed with 12 human U133A chips including 23000 probe sets.
The data compared between liraglutide and control groups showed a significant difference on glucose-induced insulin secretion, rather than viability.
Microarray analysis identified 7000 genes expressed in human islets.
Eighty genes were found to be modulated by liraglutide treatment.
Furthermore, the products of these genes are proteins involved in binding capability, enzyme activity, transporter function, signal transduction, cell proliferation, apoptosis, and cell differentiation.
Our data provides a set of information in the complex events, following the activation of the GLP-1 receptor in the islets of Langerhans.
American Psychological Association (APA)
Zhao, Xiaoning& Tang, Yongming G.& Wu, S. Vincent& Wang, Charles& Perfetti, Ricardo& Khoury, Nasif…[et al.]. 2012. The Global Transcriptional Response of Isolated Human Islets of Langerhans to Glucagon-Like Peptide-1 Receptor Agonist Liraglutide. ISRN Endocrinology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-484777
Modern Language Association (MLA)
Zhao, Xiaoning…[et al.]. The Global Transcriptional Response of Isolated Human Islets of Langerhans to Glucagon-Like Peptide-1 Receptor Agonist Liraglutide. ISRN Endocrinology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-484777
American Medical Association (AMA)
Zhao, Xiaoning& Tang, Yongming G.& Wu, S. Vincent& Wang, Charles& Perfetti, Ricardo& Khoury, Nasif…[et al.]. The Global Transcriptional Response of Isolated Human Islets of Langerhans to Glucagon-Like Peptide-1 Receptor Agonist Liraglutide. ISRN Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-484777
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484777
