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Impaired Perinatal Growth and Longevity : A Life History Perspective
Joint Authors
Gluckman, Peter D.
Vickers, Mark H.
Beedle, Alan S.
Cupido, Cinda L.
Sloboda, Deborah M.
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Life history theory proposes that early-life cues induce highly integrated responses in traits associated with energy partitioning, maturation, reproduction, and aging such that the individual phenotype is adaptively more appropriate to the anticipated environment.
Thus, maternal and/or neonatally derived nutritional or endocrine cues suggesting a threatening environment may favour early growth and reproduction over investment in tissue reserve and repair capacity.
These may directly affect longevity, as well as prioritise insulin resistance and capacity for fat storage, thereby increasing susceptibility to metabolic dysfunction and obesity.
These shifts in developmental trajectory are associated with long-term expression changes in specific genes, some of which may be underpinned by epigenetic processes.
This normative process of developmental plasticity may prove to be maladaptive in human environments in transition towards low extrinsic mortality and energy-dense nutrition, leading to the development of an inappropriate phenotype with decreased potential for longevity and/or increased susceptibility to metabolic disease.
American Psychological Association (APA)
Sloboda, Deborah M.& Beedle, Alan S.& Cupido, Cinda L.& Gluckman, Peter D.& Vickers, Mark H.. 2009. Impaired Perinatal Growth and Longevity : A Life History Perspective. Current Gerontology and Geriatrics Research،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-484786
Modern Language Association (MLA)
Sloboda, Deborah M.…[et al.]. Impaired Perinatal Growth and Longevity : A Life History Perspective. Current Gerontology and Geriatrics Research No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-484786
American Medical Association (AMA)
Sloboda, Deborah M.& Beedle, Alan S.& Cupido, Cinda L.& Gluckman, Peter D.& Vickers, Mark H.. Impaired Perinatal Growth and Longevity : A Life History Perspective. Current Gerontology and Geriatrics Research. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-484786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484786