Mild Systemic Oxidative Stress in the Subclinical Stage of Alzheimer’s Disease
Joint Authors
Freitas, Maria C. V.
Moscardi, Alcione A. V. S.
Simon, Karin A.
Ramos, Luiz R.
Azzalis, Ligia A.
Salomão, Reinaldo
Junqueira, Virgínia B. C.
Brunialti, Milena K. C.
Giavarotti, Leandro
Fonseca, Fernando L. A.
M. Montaño, Maria B. M.
Lima, Alessandra F.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Alzheimer’s disease (AD) is a late-onset, progressive degenerative disorder that affects mainly the judgment, emotional stability, and memory domains.
AD is the outcome of a complex interaction among several factors which are not fully understood yet; nevertheless, it is clear that oxidative stress and inflammatory pathways are among these factors.
65 elderly subjects (42 cognitively intact and 23 with probable Alzheimer’s disease) were selected for this study.
We evaluated erythrocyte activities of superoxide dismutase, catalase, and glutathione peroxidase as well as plasma levels of total glutathione, α-tocopherol, β-carotene, lycopene, and coenzyme Q10.
These antioxidant parameters were confronted with plasmatic levels of protein and lipid oxidation products.
Additionally, we measured basal expression of monocyte HLA-DR and CD-11b, as well as monocyte production of cytokines IL1-α, IL-6, and TNF-α.
AD patients presented lower plasmatic levels of α-tocopherol when compared to control ones and also higher basal monocyte HLA-DR expression associated with higher IL-1α production when stimulated by LPS.
These findings support the inflammatory theory of AD and point out that this disease is associated with a higher basal activation of circulating monocytes that may be a result of α-tocopherol stock depletion.
American Psychological Association (APA)
Giavarotti, Leandro& Simon, Karin A.& Azzalis, Ligia A.& Fonseca, Fernando L. A.& Lima, Alessandra F.& Freitas, Maria C. V.…[et al.]. 2013. Mild Systemic Oxidative Stress in the Subclinical Stage of Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-484803
Modern Language Association (MLA)
Giavarotti, Leandro…[et al.]. Mild Systemic Oxidative Stress in the Subclinical Stage of Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-484803
American Medical Association (AMA)
Giavarotti, Leandro& Simon, Karin A.& Azzalis, Ligia A.& Fonseca, Fernando L. A.& Lima, Alessandra F.& Freitas, Maria C. V.…[et al.]. Mild Systemic Oxidative Stress in the Subclinical Stage of Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-484803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484803