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Possible Migration and Histopathological Analysis of Injections of Polymethylmethacrylate in Wistar Rats
Joint Authors
Herdt, Marcello Alberton
de Vasconcellos, Zulmar Antonio Accioli
Ely, Jorge Bins
d'Acampora, Armando José
Wohlgemuth, Felipe Barbieri
Neves, Rodrigo d'Eça
Bastos, José Caldeira Ferreira
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To evaluate the possible migration of polymethylmethacrylate after injections in various corporal compartments of Wistar rats.
Methods.
The experimental work consisted in the injection of PMMA in corporal compartments for later histopathological analysis of the locations of implants and of distant filtering organs.
The dose applied in each implant was of 0.2 mL.
The animals were divided into groups according to the location of the implant realized: group GB had intradermic injections in the glabella.
Group SD had subdermal injections in dorsal subcutaneous tissue cells.
Group IP had intraperitoneal injections in the abdomen.
Group PD had intramuscular injections in the right rear leg.
The rats were sacrificed 30 days after realization of the implants and tissue samples from the lung, liver, spleen, and kidney, and locations of implantation were removed for histopathological analysis.
Results.
Characteristic microspheres that were compatible with the presence of PMMA in any of the histological slides analyzed were not observed.
One animal had an amorphous exogenous substance, with a histiocytic reaction.
Twelve of the 16 lungs analyzed had locations of intraalveolar hemorrhaging.
Two animals had nonspecific spleen alterations.
Conclusion.
The histopathological analysis of this study found no PMMA microspheres in any of the tissues analyzed.
American Psychological Association (APA)
Neves, Rodrigo d'Eça& Herdt, Marcello Alberton& Wohlgemuth, Felipe Barbieri& Ely, Jorge Bins& de Vasconcellos, Zulmar Antonio Accioli& Bastos, José Caldeira Ferreira…[et al.]. 2012. Possible Migration and Histopathological Analysis of Injections of Polymethylmethacrylate in Wistar Rats. ISRN Dermatology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-484811
Modern Language Association (MLA)
Neves, Rodrigo d'Eça…[et al.]. Possible Migration and Histopathological Analysis of Injections of Polymethylmethacrylate in Wistar Rats. ISRN Dermatology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-484811
American Medical Association (AMA)
Neves, Rodrigo d'Eça& Herdt, Marcello Alberton& Wohlgemuth, Felipe Barbieri& Ely, Jorge Bins& de Vasconcellos, Zulmar Antonio Accioli& Bastos, José Caldeira Ferreira…[et al.]. Possible Migration and Histopathological Analysis of Injections of Polymethylmethacrylate in Wistar Rats. ISRN Dermatology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-484811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484811