Vascular Pathology and Blood-Brain Barrier Disruption in Cognitive and Psychiatric Complications of Type 2 Diabetes Mellitus
Joint Authors
Levy, Jaime
Shalev, Hadar
Serlin, Yonatan
Source
Cardiovascular Psychiatry and Neurology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Vascular pathology is recognized as a principle insult in type 2 diabetes mellitus (T2DM).
Co-morbidities such as structural brain abnormalities, cognitive, learning and memory deficits are also prevailing in T2DM patients.
We previously suggested that microvascular pathologies involving blood-brain barrier (BBB) breakdown results in leakage of serum-derived components into the brain parenchyma, leading to neuronal dysfunction manifested as psychiatric illnesses.
The current postulate focuses on the molecular mechanisms controlling BBB permeability in T2DM, as key contributors to the pathogenesis of mental disorders in patients.
Revealing the mechanisms underlying BBB dysfunction and inflammatory response in T2DM and their role in metabolic disturbances, abnormal neurovascular coupling and neuronal plasticity, would contribute to the understanding of the mechanisms underlying psychopathologies in diabetic patients.
Establishing this link would offer new targets for future therapeutic interventions.
American Psychological Association (APA)
Serlin, Yonatan& Levy, Jaime& Shalev, Hadar. 2011. Vascular Pathology and Blood-Brain Barrier Disruption in Cognitive and Psychiatric Complications of Type 2 Diabetes Mellitus. Cardiovascular Psychiatry and Neurology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-484818
Modern Language Association (MLA)
Serlin, Yonatan…[et al.]. Vascular Pathology and Blood-Brain Barrier Disruption in Cognitive and Psychiatric Complications of Type 2 Diabetes Mellitus. Cardiovascular Psychiatry and Neurology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-484818
American Medical Association (AMA)
Serlin, Yonatan& Levy, Jaime& Shalev, Hadar. Vascular Pathology and Blood-Brain Barrier Disruption in Cognitive and Psychiatric Complications of Type 2 Diabetes Mellitus. Cardiovascular Psychiatry and Neurology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-484818
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484818