Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck Squamous Cancer-Derived ALDH1 Positive Cells
Joint Authors
Huang, Pin-I
Lo, Wen-Liang
Yu, Cheng-Chia
Chen, Yi-Wei
Hsu, Han-Shui
Tseng, Ling-Ming
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-27
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Recent studies suggest that ALDH1 is a putative marker for HNSCC-derived cancer stem cells.
However, the regulation mechanisms that maintain the stemness and metastatic capability of HNSCC-ALDH1+ cells remain unclear.
Initially, HNSCC-ALDH1+ cells from HNSCC patient showed cancer stemness properties, and high expression of Bmi1 and Snail.
Functionally, tumorigenic properties of HNSCC-ALDH1+ cells could be downregulated by knockdown of Bmi-1.
Overexpression of Bmi-1 altered in expression property ALDH1− cells to that of ALDH1+ cells.
Furthermore, knockdown of Bmi-1 enhanced the radiosensitivity of radiation-treated HNSCC-ALDH1+ cells.
Moreover, overexpression of Bmi-1 in HNSCC-ALDH1− cells increased tumor volume and number of pulmonary metastatic lesions by xenotransplant assay.
Importantly, knock-down of Bmi1 in HNSCC-ALDH1+ cells significantly decreased distant metastases in the lungs.
Clinically, coexpression of Bmi-1/Snail/ALDH1 predicted the worst prognosis in HNSCC patients.
Collectively, our data suggested that Bmi-1 plays a key role in regulating Snail expression and cancer stemness properties of HNSCC-ALDH1+ cells.
American Psychological Association (APA)
Yu, Cheng-Chia& Lo, Wen-Liang& Chen, Yi-Wei& Huang, Pin-I& Hsu, Han-Shui& Tseng, Ling-Ming. 2010. Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck Squamous Cancer-Derived ALDH1 Positive Cells. Journal of Oncology،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-484823
Modern Language Association (MLA)
Yu, Cheng-Chia…[et al.]. Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck Squamous Cancer-Derived ALDH1 Positive Cells. Journal of Oncology No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-484823
American Medical Association (AMA)
Yu, Cheng-Chia& Lo, Wen-Liang& Chen, Yi-Wei& Huang, Pin-I& Hsu, Han-Shui& Tseng, Ling-Ming. Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck Squamous Cancer-Derived ALDH1 Positive Cells. Journal of Oncology. 2010. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-484823
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484823