Towards Improved Prognostic Scores Predicting Survival in Patients with Brain Metastases : A Pilot Study of Serum Lactate Dehydrogenase Levels
Joint Authors
Nieder, Carsten
Norum, Jan
Dalhaug, Astrid
Marienhagen, Kirsten
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Accurate prognostic information is desirable when counselling patients with brain metastases regarding their therapeutic options and life expectancy.
Based on previous studies, we selected serum lactate dehydrogenase (LDH) as a promising factor on which we perform a pilot study investigating methodological aspects of biomarker studies in patients with brain metastases, before embarking on large-scale studies that will look at a larger number of candidate markers in an expanded patient cohort.
For this retrospective analysis, 100 patients with available information on LDH treated with palliative whole-brain radiotherapy were selected.
A comprehensive evaluation of different LDH-based variables was performed in uni- and multivariate tests.
Probably, the most intriguing finding was that LDH kinetics might be more important, or at least complement, information obtained from a single measurement immediately before radiotherapy.
LDH and performance status outperformed several other variables that are part of prognostic models such as recursive partitioning analyses classes and graded prognostic assessment score.
LDH kinetics might reflect disease behaviour in extracranial metastatic and primary sites without need for comprehensive imaging studies and is a quite inexpensive diagnostic test.
Based on these encouraging results, confirmatory studies in a larger cohort of patients are warranted.
American Psychological Association (APA)
Nieder, Carsten& Marienhagen, Kirsten& Dalhaug, Astrid& Norum, Jan. 2012. Towards Improved Prognostic Scores Predicting Survival in Patients with Brain Metastases : A Pilot Study of Serum Lactate Dehydrogenase Levels. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-484834
Modern Language Association (MLA)
Nieder, Carsten…[et al.]. Towards Improved Prognostic Scores Predicting Survival in Patients with Brain Metastases : A Pilot Study of Serum Lactate Dehydrogenase Levels. The Scientific World Journal No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-484834
American Medical Association (AMA)
Nieder, Carsten& Marienhagen, Kirsten& Dalhaug, Astrid& Norum, Jan. Towards Improved Prognostic Scores Predicting Survival in Patients with Brain Metastases : A Pilot Study of Serum Lactate Dehydrogenase Levels. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-484834
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484834