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Targeted Therapy in Ewing Sarcoma
Joint Authors
Lissat, A.
Kontny, U.
Chao, M. M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Despite marked improvement in the prognosis of patients with nonmetastatic Ewing sarcoma (ES), the outcome for patients with recurrent or metastatic disease remains poor.
Insight into key biologic processes in ES could provide new therapeutic targets.
The particular biologic feature of ES, the fusion of the EWS gene with a member of the ETS family of genes, is present in >95% of cases.
The EWS-ETS chimeric protein leads to aberrant transcription that promotes tumor initiation and propagation via prosurvival and antiapoptotic pathways.
Recent research has identified cooperating mutations important for ES tumorigenesis.
This paper provides a summary of the latest research in ES and discusses potential novel targets for therapy.
American Psychological Association (APA)
Lissat, A.& Chao, M. M.& Kontny, U.. 2012. Targeted Therapy in Ewing Sarcoma. ISRN Oncology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-484843
Modern Language Association (MLA)
Lissat, A.…[et al.]. Targeted Therapy in Ewing Sarcoma. ISRN Oncology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-484843
American Medical Association (AMA)
Lissat, A.& Chao, M. M.& Kontny, U.. Targeted Therapy in Ewing Sarcoma. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-484843
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484843