Effectiveness of Methylcobalamin and Folinic Acid Treatment on Adaptive Behavior in Children with Autistic Disorder Is Related to Glutathione Redox Status
Joint Authors
Walters, Laura
Melnyk, Stepan
Hubanks, Amanda
Reid, Tyra
Pavliv, Oleksandra
Fuchs, George
Frye, Richard E.
James, S. Jill
Jernigan, Stefanie
Gaylor, David W.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Treatments targeting metabolic abnormalities in children with autism are limited.
Previously we reported that a nutritional treatment significantly improved glutathione metabolism in children with autistic disorder.
In this study we evaluated changes in adaptive behaviors in this cohort and determined whether such changes are related to changes in glutathione metabolism.
Thirty-seven children diagnosed with autistic disorder and abnormal glutathione and methylation metabolism were treated with twice weekly 75 µg/Kg methylcobalamin and twice daily 400 µg folinic acid for 3 months in an open-label fashion.
The Vineland Adaptive Behavior Scale (VABS) and glutathione redox metabolites were measured at baseline and at the end of the treatment period.
Over the treatment period, all VABS subscales significantly improved with an average effect size of 0.59, and an average improvement in skills of 7.7 months.
A greater improvement in glutathione redox status was associated with a greater improvement in expressive communication, personal and domestic daily living skills, and interpersonal, play-leisure, and coping social skills.
Age, gender, and history of regression did not influence treatment response.
The significant behavioral improvements observed and the relationship between these improvements to glutathione redox status suggest that nutritional interventions targeting redox metabolism may benefit some children with autism.
American Psychological Association (APA)
Frye, Richard E.& Melnyk, Stepan& Fuchs, George& Reid, Tyra& Jernigan, Stefanie& Pavliv, Oleksandra…[et al.]. 2013. Effectiveness of Methylcobalamin and Folinic Acid Treatment on Adaptive Behavior in Children with Autistic Disorder Is Related to Glutathione Redox Status. Autism Research and Treatment،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-484876
Modern Language Association (MLA)
Frye, Richard E.…[et al.]. Effectiveness of Methylcobalamin and Folinic Acid Treatment on Adaptive Behavior in Children with Autistic Disorder Is Related to Glutathione Redox Status. Autism Research and Treatment No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-484876
American Medical Association (AMA)
Frye, Richard E.& Melnyk, Stepan& Fuchs, George& Reid, Tyra& Jernigan, Stefanie& Pavliv, Oleksandra…[et al.]. Effectiveness of Methylcobalamin and Folinic Acid Treatment on Adaptive Behavior in Children with Autistic Disorder Is Related to Glutathione Redox Status. Autism Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-484876
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484876