Direct Immunosensor Design Based on the Electrochemical Reduction of 4-((4-Nitrophenyl)ethynyl)benzenethiol Monolayers
Joint Authors
Crawley, Charlene D.
Williams, Wraegen A. M.
Rhoten, Melissa C.
Ruder, Suzanne
Williams, Dwight A.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The synthesis and characterization of novel N-arylhydroxylamine-based molecular wires are described for use in the site-directed covalent immobilization of whole IgG antibodies onto gold electrode surfaces.
The hydroxylamine, electrochemically generated in situ from reduction of the corresponding nitrobenzene, is stable under a wide range of solution conditions and reacts selectively with carbohydrate away from the antibody-binding site to allow the development of immunosensors with maximal activity.
Cyclic voltammetric responses have shown a direct correlation between the structure and length of the molecular wire and its stability and concentration at the electrode surface.
American Psychological Association (APA)
Williams, Dwight A.& Williams, Wraegen A. M.& Rhoten, Melissa C.& Crawley, Charlene D.& Ruder, Suzanne. 2011. Direct Immunosensor Design Based on the Electrochemical Reduction of 4-((4-Nitrophenyl)ethynyl)benzenethiol Monolayers. Journal of Sensors،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-484886
Modern Language Association (MLA)
Williams, Dwight A.…[et al.]. Direct Immunosensor Design Based on the Electrochemical Reduction of 4-((4-Nitrophenyl)ethynyl)benzenethiol Monolayers. Journal of Sensors No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-484886
American Medical Association (AMA)
Williams, Dwight A.& Williams, Wraegen A. M.& Rhoten, Melissa C.& Crawley, Charlene D.& Ruder, Suzanne. Direct Immunosensor Design Based on the Electrochemical Reduction of 4-((4-Nitrophenyl)ethynyl)benzenethiol Monolayers. Journal of Sensors. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-484886
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484886