Immunohistochemical Characteristics of IgG4-Related Tubulointerstitial Nephritis : Detailed Analysis of 20 Japanese Cases
Joint Authors
Yamanaka, Nobuaki
Umehara, Hisanori
Mizushima, Ichiro
Hisano, Satoshi
Imai, Naofumi
Yamamoto, Motohisa
Takahashi, Hiroki
Saeki, Takako
Nishi, Shinichi
Nakashima, Hitoshi
Yamaguchi, Yutaka
Kawano, Mitsuhiro
Saito, Takao
Source
International Journal of Rheumatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Although tubulointerstitial nephritis with IgG4+ plasma cell (PC) infiltration is a hallmark of IgG4-related kidney disease (IgG4-RKD), only a few studies are available about the minimum number of IgG4+ PC needed for diagnosis along with IgG4+/IgG+ PC ratio in the kidney.
In addition, the significance of the deposition of IgG or complement as a reflection of humoral immunity involvement is still uncertain.
In this study, we analyzed 20 Japanese patients with IgG4-RKD to evaluate the number of IgG4+ PCs along with IgG4+/IgG+ PC ratio and involvement of humoral immunity.
The average number of IgG4+ PCs was 43.8/hpf and the average IgG4+/IgG+ or IgG4+/CD138+ ratio was 53%.
IgG and C3 granular deposits on the tubular basement membrane (TBM) were detected by immunofluorescence microscopy in 13% and 47% of patients, respectively.
Nine patients had a variety of glomerular lesions, and 7 of them had immunoglobulin or complement deposition in the glomerulus.
In conclusion, we confirmed that infiltrating IgG4+ PCs > 10/hpf and/or IgG4/IgG (CD138)+ PCs > 40% was appropriate as an item of the diagnostic criteria for IgG4-RKD.
A relatively high frequency of diverse glomerular lesions with immunoglobulin or complement deposits and deposits in TBM may be evidence of immune complex involvement in IgG4-related disease.
American Psychological Association (APA)
Kawano, Mitsuhiro& Mizushima, Ichiro& Yamaguchi, Yutaka& Imai, Naofumi& Nakashima, Hitoshi& Nishi, Shinichi…[et al.]. 2012. Immunohistochemical Characteristics of IgG4-Related Tubulointerstitial Nephritis : Detailed Analysis of 20 Japanese Cases. International Journal of Rheumatology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-484889
Modern Language Association (MLA)
Kawano, Mitsuhiro…[et al.]. Immunohistochemical Characteristics of IgG4-Related Tubulointerstitial Nephritis : Detailed Analysis of 20 Japanese Cases. International Journal of Rheumatology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-484889
American Medical Association (AMA)
Kawano, Mitsuhiro& Mizushima, Ichiro& Yamaguchi, Yutaka& Imai, Naofumi& Nakashima, Hitoshi& Nishi, Shinichi…[et al.]. Immunohistochemical Characteristics of IgG4-Related Tubulointerstitial Nephritis : Detailed Analysis of 20 Japanese Cases. International Journal of Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-484889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484889