Role of Endoplasmic Reticulum Stress in Atherosclerosis and Diabetic Macrovascular Complications
Joint Authors
Chistiakov, Dimitry A.
Bobryshev, Yuri V.
Orekhov, Alexander N.
Sobenin, Igor A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-01
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Age-related changes in endoplasmic reticulum (ER) are associated with stress of this cell organelle.
Unfolded protein response (UPR) is a normal physiological reaction of a cell in order to prevent accumulation of unfolded and misfolded proteins in the ER and improve the normal ER function.
However, in pathologic conditions such as atherosclerosis, obesity, and diabetes, ER function becomes impaired, leading to the development of ER stress.
In chronic ER stress, defective posttranslational protein folding results in deposits of aberrantly folded proteins in the ER and the induction of cell apoptosis mediated by UPR sensors C/EBPα-homologous protein (CHOP) and inositol requiring protein-1 (IRE1).
Since ER stress and ER-induced cell death play a nonredundant role in the pathogenesis of atherosclerosis and diabetic macrovascular complications, pharmaceutical targeting of ER stress components and pathways may be beneficial in the treatment and prevention of cardiovascular pathology.
American Psychological Association (APA)
Chistiakov, Dimitry A.& Sobenin, Igor A.& Orekhov, Alexander N.& Bobryshev, Yuri V.. 2014. Role of Endoplasmic Reticulum Stress in Atherosclerosis and Diabetic Macrovascular Complications. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-484905
Modern Language Association (MLA)
Chistiakov, Dimitry A.…[et al.]. Role of Endoplasmic Reticulum Stress in Atherosclerosis and Diabetic Macrovascular Complications. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-484905
American Medical Association (AMA)
Chistiakov, Dimitry A.& Sobenin, Igor A.& Orekhov, Alexander N.& Bobryshev, Yuri V.. Role of Endoplasmic Reticulum Stress in Atherosclerosis and Diabetic Macrovascular Complications. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-484905
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484905