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Ceramide in Stem Cell Differentiation and Embryo Development : Novel Functions of a Topological Cell-Signaling Lipid and the Concept of Ceramide Compartments
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In the last two decades, the view on the function of ceramide as a sole metabolic precursor for other sphingolipids has completely changed.
A plethora of studies has shown that ceramide is an important lipid cell-signaling factor regulating apoptosis in a variety of cell types.
With the advent of new stem cell technologies and knockout mice for specific steps in ceramide biosynthesis, this view is about to change again.
Recent studies suggest that ceramide is a critical cell-signaling factor for stem cell differentiation and cell polarity, two processes at the core of embryo development.
This paper discusses studies on ceramide using in vitro differentiated stem cells, embryo cultures, and knockout mice with the goal of linking specific developmental stages to exciting and novel functions of this lipid.
Particular attention is devoted to the concept of ceramide as a topological cell-signaling lipid: a lipid that forms distinct structures (membrane domains and vesicles termed “sphingosome”), which confines ceramide-induced cell signaling pathways to localized and even polarized compartments.
American Psychological Association (APA)
Bieberich, Erhard. 2010. Ceramide in Stem Cell Differentiation and Embryo Development : Novel Functions of a Topological Cell-Signaling Lipid and the Concept of Ceramide Compartments. Journal of Lipids،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-484924
Modern Language Association (MLA)
Bieberich, Erhard. Ceramide in Stem Cell Differentiation and Embryo Development : Novel Functions of a Topological Cell-Signaling Lipid and the Concept of Ceramide Compartments. Journal of Lipids No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-484924
American Medical Association (AMA)
Bieberich, Erhard. Ceramide in Stem Cell Differentiation and Embryo Development : Novel Functions of a Topological Cell-Signaling Lipid and the Concept of Ceramide Compartments. Journal of Lipids. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-484924
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484924