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Development and Validation of Dissolution Test for Fluconazole Capsules by HPLC and Derivative UV Spectrophotometry
Joint Authors
Salgado, Hérida Regina Nunes
Duarte Vianna-Soares, Cristina
Corrêa, Josilene Chaves Ruela
Source
Chromatography Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The purpose of this study is to develop and validate a dissolution test for fluconazole, an antifungal used for the treatment of superficial, cutaneous, and cutaneomucous infections caused by Candida species, in capsules dosage form.
Techniques by HPLC and UV first derivative spectrophotometry (UV-FDS) were selected for quantitative evaluation.
In the development of release profile, several conditions were evaluated.
Dissolution test parameters were considered appropriate when a most discriminative release profile for fluconazole capsules was yielded.
Dissolution test conditions for fluconazole capsules were 900 mL of HCl 0.1 M, 37 ± 0.5 °C using baskets with 50 rpm for 30 min of test.
The developed HPLC and UV-FDS methods for the antifungal evaluation were selective and met requirements for an appropriate and validated method, according to ICH and USP requirements.
Both methods can be useful in the registration process of new drugs or their renewal.
For routine analysis application cost, simplicity, equipment, solvents, speed, and application to large or small workloads should be observed.
American Psychological Association (APA)
Corrêa, Josilene Chaves Ruela& Duarte Vianna-Soares, Cristina& Salgado, Hérida Regina Nunes. 2012. Development and Validation of Dissolution Test for Fluconazole Capsules by HPLC and Derivative UV Spectrophotometry. Chromatography Research International،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-484946
Modern Language Association (MLA)
Corrêa, Josilene Chaves Ruela…[et al.]. Development and Validation of Dissolution Test for Fluconazole Capsules by HPLC and Derivative UV Spectrophotometry. Chromatography Research International No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-484946
American Medical Association (AMA)
Corrêa, Josilene Chaves Ruela& Duarte Vianna-Soares, Cristina& Salgado, Hérida Regina Nunes. Development and Validation of Dissolution Test for Fluconazole Capsules by HPLC and Derivative UV Spectrophotometry. Chromatography Research International. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-484946
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484946