In Vivo Inflammation Does Not Impair ABCA1-Mediated Cholesterol Efflux Capacity of HDL
Joint Authors
Wolfkamp, Simone C. S.
Franssen, Remco
van Leuven, Sander I.
Dallinga-Thie, Geesje M.
Schimmel, Alinda W. M.
Stroes, Erik S. G.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
HDL provides atheroprotection by facilitating cholesterol efflex from lipid-laden macrophages in the vessel wall.
In vitro studies have suggested impaired efflux capacity of HDL following inflammatory changes.
We assessed the impact of acute severe sepsis and mild chronic inflammatory disease on the efflux capacity of HDL.
We hypothesize that a more severe inflammatory state leads to stronger impaired cholesterol efflux capacity.
Using lipid-laden THP1 cells and fibroblasts we were able to show that efflux capacity of HDL from both patients with severe sepsis or with Crohn's disease (active or in remission), either isolated using density gradient ultracentrifugation or using apoB precipitation, was not impaired.
Yet plasma levels of HDL cholesterol and apoA-I were markedly lower in patients with sepsis.
Based on the current observations we conclude that inflammatory disease does not interfere with the capacity of HDL to mediate cholesterol efflux.
Our findings do not lend support to the biological relevance of HDL function changes in vitro.
American Psychological Association (APA)
Franssen, Remco& Schimmel, Alinda W. M.& van Leuven, Sander I.& Wolfkamp, Simone C. S.& Stroes, Erik S. G.& Dallinga-Thie, Geesje M.. 2012. In Vivo Inflammation Does Not Impair ABCA1-Mediated Cholesterol Efflux Capacity of HDL. Cholesterol،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-484987
Modern Language Association (MLA)
Franssen, Remco…[et al.]. In Vivo Inflammation Does Not Impair ABCA1-Mediated Cholesterol Efflux Capacity of HDL. Cholesterol No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-484987
American Medical Association (AMA)
Franssen, Remco& Schimmel, Alinda W. M.& van Leuven, Sander I.& Wolfkamp, Simone C. S.& Stroes, Erik S. G.& Dallinga-Thie, Geesje M.. In Vivo Inflammation Does Not Impair ABCA1-Mediated Cholesterol Efflux Capacity of HDL. Cholesterol. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-484987
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484987