Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases
Joint Authors
Neumann, Donna M.
Bhattacharjee, Partha S.
Hsia, Victor
Nolan, Nicole M.
Lukiw, Walter J.
Hill, James M.
Clement, Christian
Webre, Jody M.
McFerrin, Harris E.
Foster, Timothy P.
Thompson, Hilary W.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-02
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
The exact mechanisms of HSV-1 establishment, maintenance, latency, reactivation, and also the courses of recurrent ocular infections remain a mystery.
Comprehensive understanding of the HSV-1 disease process could lead to prevention of HSV-1 acute infection, reactivation, and more effective treatments of recurrent ocular disease.
Animal models have been used for over sixty years to investigate our concepts and hypotheses of HSV-1 diseases.
In this paper we present descriptions and examples of rabbit and mouse eye models of HSV-1 latency, reactivation, and recurrent diseases.
We summarize studies in animal models of spontaneous and induced HSV-1 reactivation and recurrent disease.
Numerous stimuli that induce reactivation in mice and rabbits are described, as well as factors that inhibit viral reactivation from latency.
The key features, advantages, and disadvantages of the mouse and rabbit models in relation to the study of ocular HSV-1 are discussed.
This paper is pertinent but not intended to be all inclusive.
We will give examples of key papers that have reported novel discoveries related to the review topics.
American Psychological Association (APA)
Webre, Jody M.& Hill, James M.& Nolan, Nicole M.& Clement, Christian& McFerrin, Harris E.& Bhattacharjee, Partha S.…[et al.]. 2012. Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-485041
Modern Language Association (MLA)
Webre, Jody M.…[et al.]. Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-485041
American Medical Association (AMA)
Webre, Jody M.& Hill, James M.& Nolan, Nicole M.& Clement, Christian& McFerrin, Harris E.& Bhattacharjee, Partha S.…[et al.]. Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-485041
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485041