![](/images/graphics-bg.png)
Reversion of Hormone Treatment Resistance with the Addition of an mTOR Inhibitor in Endometrial Stromal Sarcoma
Joint Authors
Judson, Ian R.
Martin-Liberal, Juan
Messiou, Christina
Benson, Charlotte
Fisher, Cyril
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Endometrial stromal sarcomas (ESS) are a subtype of gynaecological sarcomas characterized by the overexpression of hormone receptors.
Hormone treatment is widely used in ESS but primary or acquired resistance is common.
The mammalian target of rapamycin (mTOR) pathway has been suggested to play a key role in the mechanisms of hormone resistance.
Recent studies in breast and prostate cancer demonstrate that this resistance can be reversed with the addition of an mTOR inhibitor.
This phenomenon has never been reported in ESS.
Methods.
We report the outcome of one patient with pretreated, progressing low grade metastatic ESS treated with medroxyprogesterone acetate in combination with the mTOR inhibitor sirolimus.
Results.
Partial response was achieved following the addition of sirolimus to the hormone treatment.
Response has been maintained for more than 2 years with minimal toxicity and treatment is ongoing.
Conclusion.
This case suggests that the resistance to the hormone manipulation in ESS can be reversed by the addition of an mTOR pathway inhibitor.
This observation is highly encouraging and deserves further investigation.
American Psychological Association (APA)
Martin-Liberal, Juan& Benson, Charlotte& Messiou, Christina& Fisher, Cyril& Judson, Ian R.. 2014. Reversion of Hormone Treatment Resistance with the Addition of an mTOR Inhibitor in Endometrial Stromal Sarcoma. Case Reports in Medicine،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-485059
Modern Language Association (MLA)
Martin-Liberal, Juan…[et al.]. Reversion of Hormone Treatment Resistance with the Addition of an mTOR Inhibitor in Endometrial Stromal Sarcoma. Case Reports in Medicine No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-485059
American Medical Association (AMA)
Martin-Liberal, Juan& Benson, Charlotte& Messiou, Christina& Fisher, Cyril& Judson, Ian R.. Reversion of Hormone Treatment Resistance with the Addition of an mTOR Inhibitor in Endometrial Stromal Sarcoma. Case Reports in Medicine. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-485059
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485059