Long-Term Leukocyte Filtration Should Be Avoided during Extracorporeal Circulation
Joint Authors
Du, Lei
Zhou, Jing
Tang, Jiali
Zhang, Chongwei
Tao, Kaiyu
Gong, Lina
Luo, Nanfu
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Filtration during extracorporeal circulation (ECC) not only removes but also activates leukocytes; therefore, long-term leukocyte filtration may cause adverse effects.
In the present study, we tested this hypothesis by priming ECC with 300 mL of canine blood and examining filtration effects in 3 groups (n=6 each) during 60 min ECC.
In the control group (Group C) blood was filtrated with an arterial filter for 60 min; in long-term (Group L) and short-term (Group S) groups, blood was filtrated with a leukocyte filter for 60 and 5 min.
We found that about 90% of leukocytes were removed after 5 min of filtration in both Groups L and S.
Although leukocyte count continued to reduce, mean fluorescent intensities of CD11/CD18, free hemoglobin, and neutrophil elastase increased in Group L and were higher than those in Groups C and S at 60 min.
Leukocyte rupture, cytoplasmic leakage, and circulating naked nuclei were also found in Group L.
The data support our hypothesis that long-term filtration can induce inflammation and lead to leukocyte destruction.
American Psychological Association (APA)
Tang, Jiali& Tao, Kaiyu& Zhou, Jing& Zhang, Chongwei& Gong, Lina& Luo, Nanfu…[et al.]. 2013. Long-Term Leukocyte Filtration Should Be Avoided during Extracorporeal Circulation. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-485097
Modern Language Association (MLA)
Tang, Jiali…[et al.]. Long-Term Leukocyte Filtration Should Be Avoided during Extracorporeal Circulation. Mediators of Inflammation No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-485097
American Medical Association (AMA)
Tang, Jiali& Tao, Kaiyu& Zhou, Jing& Zhang, Chongwei& Gong, Lina& Luo, Nanfu…[et al.]. Long-Term Leukocyte Filtration Should Be Avoided during Extracorporeal Circulation. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-485097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485097