Trains of Epidural DC Stimulation of the Cerebellum Tune Corticomotor Excitability

Joint Authors

Oulad Ben Taib, Nordeyn
Manto, Mario U.

Source

Neural Plasticity

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-05-20

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Medicine

Abstract EN

We assessed the effects of anodal/cathodal direct current stimulation (DCS) applied epidurally over the cerebellum.

We studied the excitability of both the motor cortex and the anterior horn of the spinal cord in adult rats under continuous anesthesia.

We also investigated the effects on the spatial representation of a couple of agonist/antagonist muscles on primary motor cortex.

Moreover, we evaluated the effects on the afferent inhibition in a paradigm of conditioned corticomotor responses.

Anodal DCS of the cerebellum (1) decreased the excitability of the motor cortex, (2) reduced the excitability of F waves, as shown by the decrease of both mean F/mean M ratios and persistence of F waves, (3) exerted a “smoothing effect” on corticomotor maps, reshaping the representation of muscles on the motor cortex, and (4) enhanced the afferent inhibition of conditioned motor evoked responses.

Cathodal DCS of the cerebellum exerted partially reverse effects.

DCS of the cerebellum modulates the excitability of both motor cortex and spinal cord at the level of the anterior horn.

This is the first demonstration that cerebellar DCS tunes the shape of corticomotor maps.

Our findings provide a novel mechanism by which DCS of the cerebellum exerts a remote neuromodulatory effect upon motor cortex.

American Psychological Association (APA)

Oulad Ben Taib, Nordeyn& Manto, Mario U.. 2013. Trains of Epidural DC Stimulation of the Cerebellum Tune Corticomotor Excitability. Neural Plasticity،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-485128

Modern Language Association (MLA)

Oulad Ben Taib, Nordeyn& Manto, Mario U.. Trains of Epidural DC Stimulation of the Cerebellum Tune Corticomotor Excitability. Neural Plasticity No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-485128

American Medical Association (AMA)

Oulad Ben Taib, Nordeyn& Manto, Mario U.. Trains of Epidural DC Stimulation of the Cerebellum Tune Corticomotor Excitability. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-485128

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-485128