A New Piezoelectric Actuator Induces Bone Formation In Vivo : A Preliminary Study
Joint Authors
Botelho, Maria Luísa
Reis, Joana
Marques, António Torres
Canto e Castro, Carlos
Capela e Silva, Fernando
Potes, José
Frias, Clara
Simões, José António Oliveira
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This in vivo study presents the preliminary results of the use of a novel piezoelectric actuator for orthopedic application.
The innovative use of the converse piezoelectric effect to mechanically stimulate bone was achieved with polyvinylidene fluoride actuators implanted in osteotomy cuts in sheep femur and tibia.
The biological response around the osteotomies was assessed through histology and histomorphometry in nondecalcified sections and histochemistry and immunohistochemistry in decalcified sections, namely, through Masson's trichrome, and labeling of osteopontin, proliferating cell nuclear antigen, and tartrate-resistant acid phosphatase.
After one-month implantation, total bone area and new bone area were significantly higher around actuators when compared to static controls.
Bone deposition rate was also significantly higher in the mechanically stimulated areas.
In these areas, osteopontin increased expression was observed.
The present in vivo study suggests that piezoelectric materials and the converse piezoelectric effect may be used to effectively stimulate bone growth.
American Psychological Association (APA)
Reis, Joana& Frias, Clara& Canto e Castro, Carlos& Botelho, Maria Luísa& Marques, António Torres& Simões, José António Oliveira…[et al.]. 2012. A New Piezoelectric Actuator Induces Bone Formation In Vivo : A Preliminary Study. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-485139
Modern Language Association (MLA)
Reis, Joana…[et al.]. A New Piezoelectric Actuator Induces Bone Formation In Vivo : A Preliminary Study. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-485139
American Medical Association (AMA)
Reis, Joana& Frias, Clara& Canto e Castro, Carlos& Botelho, Maria Luísa& Marques, António Torres& Simões, José António Oliveira…[et al.]. A New Piezoelectric Actuator Induces Bone Formation In Vivo : A Preliminary Study. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-485139
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485139