Experimental and Mathematical Studies on the Drug Release Properties of Aspirin Loaded Chitosan Nanoparticles
Joint Authors
Chen, Yupeng
Zhang, Yueyue
Shi, Yifei
Wan, Ajun
Shi, Yixiang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The study of drug release dynamic is aiming at understanding the process that drugs release in human body and its dynamic characteristics.
It is of great significance since these characteristics are closely related to the dose, dosage form, and effect of the drugs.
The Noyes-Whitney function is used to represent how the solid material is dissolved into solution, and it is well used in study of drug dynamic.
In this research, aspirin (acetylsalicylic acid (ASA)) has been encapsulated with different grades of chitosan (CS) varying in molecular weight (Mw) for the purpose of controlled release.
The encapsulation was accomplished by ionic gelation technology based on assembly of positively charged chitosan and negatively charged sodium tripolyphosphate (TPP).
The encapsulation efficiency, loading capacity, and drug release behavior of aspirin loaded chitosan nanoparticles (CS-NPs) were studied.
It was found that the concentration of TPP and Aspirin, molecular weights of chitosan have important effect on the drug release patterns from chitosan nanoparticles.
The results for simulation studies show that the Noyes-Whitney equation can be successfully used to interpret the drug release characteristics reflected by our experimental data.
American Psychological Association (APA)
Shi, Yixiang& Wan, Ajun& Shi, Yifei& Zhang, Yueyue& Chen, Yupeng. 2014. Experimental and Mathematical Studies on the Drug Release Properties of Aspirin Loaded Chitosan Nanoparticles. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-485155
Modern Language Association (MLA)
Shi, Yixiang…[et al.]. Experimental and Mathematical Studies on the Drug Release Properties of Aspirin Loaded Chitosan Nanoparticles. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-485155
American Medical Association (AMA)
Shi, Yixiang& Wan, Ajun& Shi, Yifei& Zhang, Yueyue& Chen, Yupeng. Experimental and Mathematical Studies on the Drug Release Properties of Aspirin Loaded Chitosan Nanoparticles. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-485155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485155