Polymorphism and Balancing Selection of MHC Class II DAB Gene in 7 Selective Flounder (Paralichthys olivaceus) Families
Joint Authors
Liao, Xiao-Lin
Liu, Yang
Du, Min
Chen, Song-lin
Gao, Feng-tao
Wang, Lei
Liang, You
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In order to determine the genetic variation of the MHC class IIB exon2 allele in the offspring, 700 fry from seven families of Japanese flounder challenged with V.
anguillarum were studied, and different mortality rates were found in those families.
Five to ten surviving and dead fry from each of the seven families were selected to study the MHC class II B exon2 gene with PCR and a direct sequencing method.
One hundred and sixteen different exon2 sequences were found and 116 different alleles were identified, while a minimum of four loci were revealed in the MHC class II B exon2 gene.
The ratio (dN/dS) of nonsynonymous substitution (dN) to synonymous substitutions (dS) in the peptide-binding region (PBR) of the MHC class IIB gene was 6.234, which indicated that balancing selection is acting on the MHC class IIB genes.
The MHC IIB alleles were thus being passed on to their progeny.
Some alleles were significantly more frequent in surviving than dead individuals.
All together our data suggested that the alleles Paol-DAB*4301, Paol-DAB*4601, Paol-DAB*4302, Paol-DAB*3803, and Paol-DAB*4101 were associated with resistance to V.
anguillarum in flounder.
American Psychological Association (APA)
Du, Min& Chen, Song-lin& Liang, You& Wang, Lei& Gao, Feng-tao& Liu, Yang…[et al.]. 2011. Polymorphism and Balancing Selection of MHC Class II DAB Gene in 7 Selective Flounder (Paralichthys olivaceus) Families. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-485156
Modern Language Association (MLA)
Du, Min…[et al.]. Polymorphism and Balancing Selection of MHC Class II DAB Gene in 7 Selective Flounder (Paralichthys olivaceus) Families. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-485156
American Medical Association (AMA)
Du, Min& Chen, Song-lin& Liang, You& Wang, Lei& Gao, Feng-tao& Liu, Yang…[et al.]. Polymorphism and Balancing Selection of MHC Class II DAB Gene in 7 Selective Flounder (Paralichthys olivaceus) Families. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-485156
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485156