Attenuation of Diabetic Nephropathy in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats with a Combination of Chinese Herbs (Tangshen Formula)
Joint Authors
Sha, Hong
Li, Ping
Zhang, Haojun
Gong, Yuewen
Li, Jing
Burczynski, Frank J.
Choy, Patrick
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Diabetic nephropathy is one of the most significant microvascular complications in patients with type 2 diabetics.
The concise mechanism of diabetic nephropathy is unknown and there is no successful treatment.
The objective of study was to investigate effects of Chinese herbs (Tangshen Formula) on diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
OLETF rats and LETO rats were divided into four groups: LETO control, OLETF diabetics, OLETF diabetics treated with Tangshen Formula, and OLETF diabetics treated with Monopril.
Body weight, blood glucose, and 24 h urinary proteins were measured once every four weeks.
Blood samples and kidney tissues were obtained for analyses of total cholesterol, triglyceride, whole blood viscosity, plasma viscosity, and pathohistological examination at 36 and 56 weeksrespectively.
Untreated OLETF rats displayed diabetic nephropathy over the study period.
Treatment of OLETF rats with Tangshen Formula attenuated the increases in blood glucose, body weight, 24 h urinary protein content, serum total cholesterol, whole blood viscosity and plasma viscosity at certain time.
Treatment with Tangshen Formula also reduced glomerulosclerotic index and interstitial fibrotic index seen in OLETF rats.
In conclusion, Tangshen Formula could attenuate the development of diabetic nephropathy in OLETF rat diabetic model.
American Psychological Association (APA)
Zhang, Haojun& Li, Ping& Burczynski, Frank J.& Gong, Yuewen& Choy, Patrick& Sha, Hong…[et al.]. 2011. Attenuation of Diabetic Nephropathy in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats with a Combination of Chinese Herbs (Tangshen Formula). Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-485168
Modern Language Association (MLA)
Zhang, Haojun…[et al.]. Attenuation of Diabetic Nephropathy in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats with a Combination of Chinese Herbs (Tangshen Formula). Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-485168
American Medical Association (AMA)
Zhang, Haojun& Li, Ping& Burczynski, Frank J.& Gong, Yuewen& Choy, Patrick& Sha, Hong…[et al.]. Attenuation of Diabetic Nephropathy in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats with a Combination of Chinese Herbs (Tangshen Formula). Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-485168
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485168