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Effects of Chronic Mild Stress on the Development of Atherosclerosis and Expression of Toll-Like Receptor 4 Signaling Pathway in Adolescent Apolipoprotein E Knockout Mice
Joint Authors
Peng, Kuang
Tang, Chaoke
Yang, Yongzong
Gu, Hongfeng
Sun, Hui
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Here, we investigated the effect of chronic mild stress (CMS) on the development of atherosclerosis as well as the expression of Toll-like receptors (TLRs) signaling pathway in adolescent apolipoprotein E knockout (apoE-/-) mice.
Mice were subjected to daily CMS for 0, 4, and 12 weeks, respectively.
To identify the expression of Toll-like receptor 4 signaling pathway in adolescent apolipoprotein E knockout mice subjected to CMS, we compared gene expression in aortas of stressed and unstressed mice using TLRs signaling pathway real-time PCR microarrays consisting of 87 genes.
We found that atherosclerosis lesions both in aortic tress and sinuses of CMS mice were significantly increased linearly in response to duration of CMS exposure.
Among 87 genes analyzed, 15 genes were upregulated in stressed mice, especially TLR4, myeloid differentiation factor 88 (MyD88), and IL-1β, and 28 genes were downregulated compared with nonstressed mice.
CMS mice demonstrated markedly increased aortic atherosclerosis that were associated with significant increases in levels of expression of TLR4, MyD88, nuclear factor κB (NF-κB), MCP-1, IL-1β, TNF-α, and sICAM-1.
Taken together, our results suggest an important role for TLR4 signaling pathway in atherosclerosis in a CMS mouse model.
American Psychological Association (APA)
Gu, Hongfeng& Tang, Chaoke& Peng, Kuang& Sun, Hui& Yang, Yongzong. 2009. Effects of Chronic Mild Stress on the Development of Atherosclerosis and Expression of Toll-Like Receptor 4 Signaling Pathway in Adolescent Apolipoprotein E Knockout Mice. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-13.
https://search.emarefa.net/detail/BIM-485178
Modern Language Association (MLA)
Gu, Hongfeng…[et al.]. Effects of Chronic Mild Stress on the Development of Atherosclerosis and Expression of Toll-Like Receptor 4 Signaling Pathway in Adolescent Apolipoprotein E Knockout Mice. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-13.
https://search.emarefa.net/detail/BIM-485178
American Medical Association (AMA)
Gu, Hongfeng& Tang, Chaoke& Peng, Kuang& Sun, Hui& Yang, Yongzong. Effects of Chronic Mild Stress on the Development of Atherosclerosis and Expression of Toll-Like Receptor 4 Signaling Pathway in Adolescent Apolipoprotein E Knockout Mice. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-13.
https://search.emarefa.net/detail/BIM-485178
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485178