The Double-Edged Sword in Pathogenic Trypanosomatids : The Pivotal Role of Mitochondria in Oxidative Stress and Bioenergetics
Joint Authors
Menna-Barreto, Rubem Figueiredo Sadok
de Castro, Solange Lisboa
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The pathogenic trypanosomatids Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp.
are the causative agents of African trypanosomiasis, Chagas disease, and leishmaniasis, respectively.
These diseases are considered to be neglected tropical illnesses that persist under conditions of poverty and are concentrated in impoverished populations in the developing world.
Novel efficient and nontoxic drugs are urgently needed as substitutes for the currently limited chemotherapy.
Trypanosomatids display a single mitochondrion with several peculiar features, such as the presence of different energetic and antioxidant enzymes and a specific arrangement of mitochondrial DNA (kinetoplast DNA).
Due to mitochondrial differences between mammals and trypanosomatids, this organelle is an excellent candidate for drug intervention.
Additionally, during trypanosomatids’ life cycle, the shape and functional plasticity of their single mitochondrion undergo profound alterations, reflecting adaptation to different environments.
In an uncoupling situation, the organelle produces high amounts of reactive oxygen species.
However, these species role in parasite biology is still controversial, involving parasite death, cell signalling, or even proliferation.
Novel perspectives on trypanosomatid-targeting chemotherapy could be developed based on better comprehension of mitochondrial oxidative regulation processes.
American Psychological Association (APA)
Menna-Barreto, Rubem Figueiredo Sadok& de Castro, Solange Lisboa. 2014. The Double-Edged Sword in Pathogenic Trypanosomatids : The Pivotal Role of Mitochondria in Oxidative Stress and Bioenergetics. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-485192
Modern Language Association (MLA)
Menna-Barreto, Rubem Figueiredo Sadok& de Castro, Solange Lisboa. The Double-Edged Sword in Pathogenic Trypanosomatids : The Pivotal Role of Mitochondria in Oxidative Stress and Bioenergetics. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-485192
American Medical Association (AMA)
Menna-Barreto, Rubem Figueiredo Sadok& de Castro, Solange Lisboa. The Double-Edged Sword in Pathogenic Trypanosomatids : The Pivotal Role of Mitochondria in Oxidative Stress and Bioenergetics. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-485192
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485192