Mechanisms of HIV Transcriptional Regulation and Their Contribution to Latency
Joint Authors
Henderson, Andrew J.
Schiralli Lester, Gillian M.
Source
Molecular Biology International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Long-lived latent HIV-infected cells lead to the rebound of virus replication following antiretroviral treatment interruption and present a major barrier to eliminating HIV infection.
These latent reservoirs, which include quiescent memory T cells and tissue-resident macrophages, represent a subset of cells with decreased or inactive proviral transcription.
HIV proviral transcription is regulated at multiple levels including transcription initiation, polymerase recruitment, transcription elongation, and chromatin organization.
How these biochemical processes are coordinated and their potential role in repressing HIV transcription along with establishing and maintaining latency are reviewed.
American Psychological Association (APA)
Schiralli Lester, Gillian M.& Henderson, Andrew J.. 2012. Mechanisms of HIV Transcriptional Regulation and Their Contribution to Latency. Molecular Biology International،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-485201
Modern Language Association (MLA)
Schiralli Lester, Gillian M.& Henderson, Andrew J.. Mechanisms of HIV Transcriptional Regulation and Their Contribution to Latency. Molecular Biology International No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-485201
American Medical Association (AMA)
Schiralli Lester, Gillian M.& Henderson, Andrew J.. Mechanisms of HIV Transcriptional Regulation and Their Contribution to Latency. Molecular Biology International. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-485201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485201