Surgical Treatment of Patients with Lennox-Gastaut Syndrome Phenotype
Joint Authors
Oommen, Joseph
An, Ning
Singh, Prabhdeep
Yang, Hui
Gao, Chang-Qing
Yin, Qing
Liao, Wei
Yang, Mei-Hua
Fang, Xiang
Liu, Shi-Yong
Liu, Yong
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Lennox-Gastaut syndrome (LGS) is a devastating and refractory generalized epilepsy affecting children and adolescents.
In this study we report the results of resective surgery in 18 patients with LGS phenotype who underwent single-lobe/lesionectomy or multilobe resection plus multiple subpial transection and/or callosotomy.
After surgery, seven patients became completely seizure-free (Engel Class I) and five almost seizure-free (Engel Class II).
Additional four had significant seizure control (Engel Class III), and two had no change in seizure frequency (Engel Class IV).
Of the 4 patients without any lesion on brain MRI, 2 ended with Engel Class II, 1 with III and the other with IV in Engels’ classification.
Mean intelligence quotient (IQ) increased from 56.1 ± 8.1 (mean ± SD) before operation to 67.4 ± 8.2 (mean ± SD) after operation, a significant improvement (P=0.001).
Results also indicated that the younger the patient at surgery, or the shorter the interval between onset of seizure and resective operation, the better the intellectual outcome.
Our data suggest that resective epilepsy surgery can be successful in patients with LGS phenotype as long as the EEG shows dominance of discharges in one hemisphere and corresponding ipsilateral imaging findings, even with contralateral ictal discharges.
American Psychological Association (APA)
Liu, Shi-Yong& An, Ning& Fang, Xiang& Singh, Prabhdeep& Oommen, Joseph& Yin, Qing…[et al.]. 2012. Surgical Treatment of Patients with Lennox-Gastaut Syndrome Phenotype. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-485218
Modern Language Association (MLA)
Liu, Shi-Yong…[et al.]. Surgical Treatment of Patients with Lennox-Gastaut Syndrome Phenotype. The Scientific World Journal No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-485218
American Medical Association (AMA)
Liu, Shi-Yong& An, Ning& Fang, Xiang& Singh, Prabhdeep& Oommen, Joseph& Yin, Qing…[et al.]. Surgical Treatment of Patients with Lennox-Gastaut Syndrome Phenotype. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-485218
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485218