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Functional Consequences of the Disturbances in the GABA-Mediated Inhibition Induced by Injuriesin the Cerebral Cortex
Joint Authors
Mittmann, Thomas
Imbrosci, Barbara
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Cortical injuries are often reported to induce a suppression of the intracortical GABAergic inhibition in the surviving, neighbouring neuronal networks.
Since GABAergic transmission provides the main source of inhibition in the mammalian brain, this condition may lead to hyperexcitability and epileptiform activity of cortical networks.
However, inhibition plays also a crucial role in limiting the plastic properties of neuronal circuits, and as a consequence, interventions aiming to reestablish a normal level of inhibition might constrain the plastic capacity of the cortical tissue.
A promising strategy to minimize the deleterious consequences of a modified inhibitory transmission without preventing the potential beneficial effects on cortical plasticity may be to unravel distinct GABAergic signaling pathways separately mediating these positive and negative events.
Here, gathering data from several recent studies, we provide new insights to better face with this “double coin” condition in the attempt to optimize the functional recovery of patients.
American Psychological Association (APA)
Imbrosci, Barbara& Mittmann, Thomas. 2011. Functional Consequences of the Disturbances in the GABA-Mediated Inhibition Induced by Injuriesin the Cerebral Cortex. Neural Plasticity،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-485226
Modern Language Association (MLA)
Imbrosci, Barbara& Mittmann, Thomas. Functional Consequences of the Disturbances in the GABA-Mediated Inhibition Induced by Injuriesin the Cerebral Cortex. Neural Plasticity No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-485226
American Medical Association (AMA)
Imbrosci, Barbara& Mittmann, Thomas. Functional Consequences of the Disturbances in the GABA-Mediated Inhibition Induced by Injuriesin the Cerebral Cortex. Neural Plasticity. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-485226
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485226