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Differential Control of Growth, Apoptotic Activity, and Gene Expression in Human Breast Cancer Cells by Extracts Derived from Medicinal Herbs Zingiber officinale
Joint Authors
Rahmy, Tarek R.
Baeshen, Nabih A.
Elkady, Ayman I.
Abuzinadah, Osama A.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The present study aimed to examine the antiproliferative potentiality of an extract derived from the medicinal plant ginger (Zingiber officinale) on growth of breast cancer cells.
Ginger treatment suppressed the proliferation and colony formation in breast cancer cell lines, MCF-7 and MDA-MB-231.
Meanwhile, it did not significantly affect viability of nontumorigenic normal mammary epithelial cell line (MCF-10A).
Treatment of MCF-7 and MDA-MB-231 with ginger resulted in sequences of events marked by apoptosis, accompanied by loss of cell viability, chromatin condensation, DNA fragmentation, activation of caspase 3, and cleavage of poly(ADP-ribose) polymerase.
At the molecular level, the apoptotic cell death mediated by ginger could be attributed in part to upregulation of Bax and downregulation of Bcl-2 proteins.
Ginger treatment downregulated expression of prosurvival genes, such as NF-κB, Bcl-X, Mcl-1, and Survivin, and cell cycle-regulating proteins, including cyclin D1 and cyclin-dependent kinase-4 (CDK-4).
On the other hand, it increased expression of CDK inhibitor, p21.
It also inhibited the expression of the two prominent molecular targets of cancer, c-Myc and the human telomerase reverse transcriptase (hTERT).
These findings suggested that the ginger may be a promising candidate for the treatment of breast carcinomas.
American Psychological Association (APA)
Elkady, Ayman I.& Abuzinadah, Osama A.& Baeshen, Nabih A.& Rahmy, Tarek R.. 2012. Differential Control of Growth, Apoptotic Activity, and Gene Expression in Human Breast Cancer Cells by Extracts Derived from Medicinal Herbs Zingiber officinale. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-485231
Modern Language Association (MLA)
Elkady, Ayman I.…[et al.]. Differential Control of Growth, Apoptotic Activity, and Gene Expression in Human Breast Cancer Cells by Extracts Derived from Medicinal Herbs Zingiber officinale. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-485231
American Medical Association (AMA)
Elkady, Ayman I.& Abuzinadah, Osama A.& Baeshen, Nabih A.& Rahmy, Tarek R.. Differential Control of Growth, Apoptotic Activity, and Gene Expression in Human Breast Cancer Cells by Extracts Derived from Medicinal Herbs Zingiber officinale. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-485231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485231