Humoral Immune Response to Keyhole Limpet Haemocyanin, the Protein Carrier in Cancer Vaccines
Joint Authors
Kantele, Anu
Zivny, J.
Mestecky, Jiri
Kantele, J. M.
Häkkinen, M. P.
Elson, C. O.
Source
Clinical and Developmental Immunology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Keyhole limpet haemocyanin (KLH) appears to be a promising protein carrier for tumor antigens in numerous cancer vaccine candidates.
The humoral immune response to KLH was characterized at the single-cell level with ELISPOT combined with separations of cell populations according to their expression of homing receptors (HRs).
The analysis of HR expressions is expected to reveal the targeting of the immune response in the body.
Eight orally primed and four nonprimed volunteers received KLH-vaccine subcutaneously.
Circulating KLH-specific plasmablasts were found in all volunteers, 60 KLH-specific plasmablasts/106 PBMC in the nonprimed and 136/106 in the primed group.
The proportion of L-selectin+ plasmablasts proved high and integrin α4β7+ low.
KLH serving as protein carrier in several vaccines, the homing profile of KLH-specific response may be applicable to the cancer antigen parts in the same vaccines.
The present data reflect a systemic homing profile, which appears advantageous for the targeting of immune response to cancer vaccines.
American Psychological Association (APA)
Kantele, Anu& Häkkinen, M. P.& Zivny, J.& Elson, C. O.& Mestecky, Jiri& Kantele, J. M.. 2011. Humoral Immune Response to Keyhole Limpet Haemocyanin, the Protein Carrier in Cancer Vaccines. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-485236
Modern Language Association (MLA)
Kantele, Anu…[et al.]. Humoral Immune Response to Keyhole Limpet Haemocyanin, the Protein Carrier in Cancer Vaccines. Clinical and Developmental Immunology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-485236
American Medical Association (AMA)
Kantele, Anu& Häkkinen, M. P.& Zivny, J.& Elson, C. O.& Mestecky, Jiri& Kantele, J. M.. Humoral Immune Response to Keyhole Limpet Haemocyanin, the Protein Carrier in Cancer Vaccines. Clinical and Developmental Immunology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-485236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485236