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Thrombomodulin : A Bifunctional Modulator of Inflammation and Coagulation in Sepsis
Joint Authors
Okamoto, Takayuki
Tanigami, Hironobu
Suzuki, Koji
Shimaoka, Motomu
Source
Critical Care Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Deregulated interplay between inflammation and coagulation plays a pivotal role in the pathogenesis of sepsis.
Therapeutic approaches that simultaneously target both inflammation and coagulation hold great promise for the treatment of sepsis.
Thrombomodulin is an endogenous anticoagulant protein that, in cooperation with protein C and thrombin-activatable fibrinolysis inhibitor, serves to maintain the endothelial microenvironment in an anti-inflammatory and anticoagulant state.
A recombinant soluble form of thrombomodulin has been approved to treat patients suffering from disseminated intravascular coagulation (DIC) and has thus far shown greater therapeutic potential than heparin.
A phase II clinical trial is currently underway in the USA to study the efficacy of thrombomodulin for the treatment of sepsis with DIC complications.
This paper focuses on the critical roles that thrombomodulin plays at the intersection of inflammation and coagulation and proposes the possible existence of interactions with integrins via protein C.
Finally, we provide a rationale for the clinical application of thrombomodulin for alleviating sepsis.
American Psychological Association (APA)
Okamoto, Takayuki& Tanigami, Hironobu& Suzuki, Koji& Shimaoka, Motomu. 2012. Thrombomodulin : A Bifunctional Modulator of Inflammation and Coagulation in Sepsis. Critical Care Research and Practice،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-485247
Modern Language Association (MLA)
Okamoto, Takayuki…[et al.]. Thrombomodulin : A Bifunctional Modulator of Inflammation and Coagulation in Sepsis. Critical Care Research and Practice No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-485247
American Medical Association (AMA)
Okamoto, Takayuki& Tanigami, Hironobu& Suzuki, Koji& Shimaoka, Motomu. Thrombomodulin : A Bifunctional Modulator of Inflammation and Coagulation in Sepsis. Critical Care Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-485247
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485247