Regulation of Cell Proliferation and Differentiation by PPARβδ
Joint Authors
Müller-Brüsselbach, Sabine
Müller, Rolf
Rieck, Markus
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-09-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) is a ligand-activated transcription factor with essential functions in the regulation of lipid catabolism, glucose homeostasis, and inflammation, which makes it a potentially relevant drug target for the treatment of major human diseases.
In addition, there is strong evidence that PPARβ/δ modulates oncogenic signaling pathways and tumor growth.
Consistent with these observations, numerous reports have clearly documented a role for PPARβ/δ in cell cycle control, differentiation, and apoptosis.
However, the precise role of PPARβ/δ in tumorigenesis and cell proliferation remains controversial.
This review summarizes our current knowledge and proposes a model corroborating the discrepant data in this area of research.
American Psychological Association (APA)
Müller, Rolf& Rieck, Markus& Müller-Brüsselbach, Sabine. 2008. Regulation of Cell Proliferation and Differentiation by PPARβδ. PPAR Research،Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-485277
Modern Language Association (MLA)
Müller, Rolf…[et al.]. Regulation of Cell Proliferation and Differentiation by PPARβδ. PPAR Research No. 2008 (2008), pp.1-5.
https://search.emarefa.net/detail/BIM-485277
American Medical Association (AMA)
Müller, Rolf& Rieck, Markus& Müller-Brüsselbach, Sabine. Regulation of Cell Proliferation and Differentiation by PPARβδ. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-485277
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485277