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Pharmacokinetics of Photogem Using Fluorescence Spectroscopy in Dimethylhydrazine-Induced Murine Colorectal Carcinoma
Joint Authors
Ferreira, Juliana
Bagnato, Vanderlei Salvador
Hage, Raduan
Plapler, Hélio
Vollet-Filho, José Dirceu
Source
International Journal of Photoenergy
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study aimed to investigate the pharmacokinetics of a hematoporphyrin derivative in colonic tumors induced by dimethylhydrazine and adjacent normal colon in Wistar rats using an in vivo fluorescence spectroscopy technique.
In conventional clinical application of photodynamic therapy, the interval between photosensitizer (PS) administration and lesion illumination is often standardized without taking into account variations due to the type or localization of the tumor and intrinsic differences in the microcirculation and vascular permeability of each target organ.
The analysis of the fluorescence spectra was based on the intensity of porphyrin emission band centered at around 620 nm in normal colon and colon tumors.
The photosensitizer fluorescence intensity rapidly grew for carcinoma and normal colon, reaching the maximum values 1 and 3 hours after PS injection, respectively.
Data presented here allow us to verify that the best compromise between selectivity and drug concentration for colon carcinoma in rats took place in the interval between 1 to 4 h after PS injection.
American Psychological Association (APA)
Hage, Raduan& Ferreira, Juliana& Bagnato, Vanderlei Salvador& Vollet-Filho, José Dirceu& Plapler, Hélio. 2012. Pharmacokinetics of Photogem Using Fluorescence Spectroscopy in Dimethylhydrazine-Induced Murine Colorectal Carcinoma. International Journal of Photoenergy،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-485316
Modern Language Association (MLA)
Hage, Raduan…[et al.]. Pharmacokinetics of Photogem Using Fluorescence Spectroscopy in Dimethylhydrazine-Induced Murine Colorectal Carcinoma. International Journal of Photoenergy No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-485316
American Medical Association (AMA)
Hage, Raduan& Ferreira, Juliana& Bagnato, Vanderlei Salvador& Vollet-Filho, José Dirceu& Plapler, Hélio. Pharmacokinetics of Photogem Using Fluorescence Spectroscopy in Dimethylhydrazine-Induced Murine Colorectal Carcinoma. International Journal of Photoenergy. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-485316
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485316