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The Role of Oxidative Stress and Inflammation in Cardiovascular Aging
Joint Authors
Wan, Wenbin
Kalionis, Bill
Wu, Junzhen
Xia, Shi-Jin
Sun, Tao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Age is an independent risk factor of cardiovascular disease, even in the absence of other traditional factors.
Emerging evidence in experimental animal and human models has emphasized a central role for two main mechanisms of age-related cardiovascular disease: oxidative stress and inflammation.
Excess reactive oxygen species (ROS) and superoxide generated by oxidative stress and low-grade inflammation accompanying aging recapitulate age-related cardiovascular dysfunction, that is, left ventricular hypertrophy, fibrosis, and diastolic dysfunction in the heart as well as endothelial dysfunction, reduced vascular elasticity, and increased vascular stiffness.
We describe the signaling involved in these two main mechanisms that include the factors NF-κB, JunD, p66Shc, and Nrf2.
Potential therapeutic strategies to improve the cardiovascular function with aging are discussed, with a focus on calorie restriction, SIRT1, and resveratrol.
American Psychological Association (APA)
Wu, Junzhen& Xia, Shi-Jin& Kalionis, Bill& Wan, Wenbin& Sun, Tao. 2014. The Role of Oxidative Stress and Inflammation in Cardiovascular Aging. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-485320
Modern Language Association (MLA)
Wu, Junzhen…[et al.]. The Role of Oxidative Stress and Inflammation in Cardiovascular Aging. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-485320
American Medical Association (AMA)
Wu, Junzhen& Xia, Shi-Jin& Kalionis, Bill& Wan, Wenbin& Sun, Tao. The Role of Oxidative Stress and Inflammation in Cardiovascular Aging. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-485320
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485320